Journal Publications - Buckley Lab

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1. McDonnell E.E., Barcellona M.N., Wilson N., Ní Néill T., Brama P.A.J., Cunniffe G., Darwish S., Butler J.S. and Buckley C.T. Preclinical to Clinical Translation for Intervertebral Disc Repair: Effects of Species-Specific Scale, Metabolism and Matrix Synthesis Rates on Cell-Based Regeneration. JOR Spine 6(3): e1279, 2023

2. Basatvat S., Bach F., Barcellona M.N., Binch A.L., Buckley C.T., Bueno B., Chahine N., Chee A., Creemers L., Dudli S., Fearing B., Ferguson S., Gansau J., Gantenbein B., Gawri R., Glaeser J., Grad S., Guerrero J., Haglund L., Hernandez P., Hoyland J., Huang C., Iatridis J.C., Illien-Junger S., Ito K., Jing L., Kaito T., Kraus P., Kushioka J., Laagland L., Lang G., Leung V., Li Z., Lufkin T., McDonnell E., O'Connell G., Panebianco C.J., Presciutti S., Rao S., Richardson S., Romereim S., Salzer E., Schmitz T., Schol J., Setton L., Sheyn D., Snuggs J., Sun Y., Tan X., Tryfonidou M., Van Maanen J., Vo N., Wang D., Williams B., Williams R., Yoon ST. and Le Maitre CL. Harmonization and standardization of nucleus pulposus cell culture methods. JOR Spine 6(1):e1238, 2023

3. McDonnell E.E. and Buckley C.T. Two- and three-dimensional in vitro nucleus pulposus cultures: An in silico analysis of local nutrient microenvironments. JOR Spine, 5(3): e1222, 2022

4. Barcellona M., Samuel S., McDonnell E and Buckley C.T. Rat tail models for assessment of injectable nucleus pulposus regeneration strategies. JOR Spine, 5(3): e1216, 2022

5. Browe D.C., Burdis R., Diaz Payno P., Freeman F.E., Nulty J.M., Buckley C.T., Brama P.A.J. and Kelly, D.J. Promoting endogenous articular cartilage regeneration using extracellular matrix scaffolds. Materials Bio Today, 16:100343, 2022

6. Browe D.C., Díaz-Payno P.J., Freeman F.E., Schipani, R., Burdis R., Ahern D.P, Nulty J.M., Guler S., Randall L.D., Buckley C.T., Brama P.A.J. and Kelly, D.J. Bilayered extracellular matrix derived scaffolds with anisotropic pore architecture guide tissue organization during osteochondral defect repair Acta Biomaterialia, 143:266-281, 2022

7. Samuel S., McDonnell E.E. and Buckley C.T. Effects of growth factor combinations on the matrix synthesis of nucleus pulposus and nasoseptal chondrocyte self-assembled microtissues. Applied Sciences. Appl. Sci. 12(3), 1453, 2022

8. McDonnell E.E. and Buckley C.T. Consolidating and re-evaluating the human disc nutrient microenvironment. JOR Spine, 5(1):e1192, 2022

9. Hibbitts A.J., Koci Z., Kneafsey S., Zilic L., Dervan A., Hinton P., Chen G., Cavanagh B., Buckley C.T., Archibald S.J. and O’Brien F.J. Multi-factorial nerve guidance conduit engineering improves outcomes in inflammation, angiogenesis and large defect nerve repair. Matrix Biology, 106, 34-57, 2022

10. Carroll, S.F., Buckley, C.T., Kelly, D.J. Measuring and modelling oxygen transport and consumption in 3D hydrogels containing chondrocytes and stem cells of different tissue origins. Frontiers in Bioengineering and Biotechnology, 9:591126, 2021

11. McDonnell E.E. and Buckley C.T. Investigating the physiological relevance of ex vivo disc organ culture nutrient microenvironments using in-silico modelling and experimental validation. JOR Spine 4(2):e1141, 2021

12. Gansau J. and Buckley C.T. Priming as a strategy to overcome detrimental pH effects on cells for intervertebral disc regeneration. eCM 41: 153-169, 2021

13. Borrelli C. and Buckley C.T. Synergistic effects of acidic pH and pro-inflammatory cytokines IL-1β and TNF-α for cell-based intervertebral disc regeneration, Applied Sciences. 10(24):9009, 2020

14. Borrelli C. and Buckley C.T. Injectable disc-derived ECM hydrogel functionalised with chondroitin sulfate for intervertebral disc regeneration. Acta Biomaterialia. 117: 142-155, 2020

15. Browe, D.C., Mahon, O.R., Diaz Payno, P., Cassidy, N., Dudurych, I., Dunne, A., Buckley, C.T. and Kelly, D.J. Glyoxal cross-linking of solubilised extracellular matrix to produce highly porous, elastic and chondro-permissive scaffolds for orthopaedic tissue engineering. Journal of Biomedical Materials Research: Part A 107(10): 1549-3296, 2019

16. Naqvi S.M., Gansau J., Gibbons, D.L. and Buckley C.T. In vitro co-culture and ex vivo organ culture assessment of primed and cryopreserved stromal cell microcapsules for intervertebral disc regeneration. eCM 37: 134-152, 2019

17. Smith, L.J., Silverman L., Sakai, D., Lotz, J.C., Le Maitre, C.L., Malhotra, N.R., Mauck, R.L., Buckley, C.T. Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS Spine Section. JOR Spine 1(4):e1036, 2018

18. Buckley C.T., Hoyland J.A., Fujii K., Pandit A., Iatridis J.C. and Grad S. Critical aspects and challenges for intervertebral disc repair and regeneration - Harnessing advances in tissue engineering. JOR Spine, 1(3):e1029, 2018

19. Gansau, J. and Buckley C.T. Incorporation of collagen and hyaluronic acid to enhance the bioactivity of fibrin-based hydrogels for nucleus pulposus regeneration. Journal of Functional Biomaterials, 9(3):43, 2018

20. Gansau, J., Kelly, L.J. and Buckley C.T Influence of key processing parameters and seeding density effects of microencapsulated chondrocytes fabricated using electrohydrodynamic spraying. Biofabrication , 10(3):035011, 2018

21. Naqvi S.M., Gansau J. and Buckley C.T. Priming and cryopreservation of microencapsulated marrow stromal cells as a strategy for intervertebral disc regeneration. Biomed. Mater. 14;13(3):034106, 2018

22. Vedicherla S.V., Romanazzo S., Kelly D.J., Buckley C.T.* and Moran C.J.* Chondrocyte based Intraoperative Processing Strategies for the Biological Augmentation of a Polyurethane Meniscal Replacement. Connective Tissue Research, 59(4):381-392, 2018. * Both authors contributed equally to this study.

23. Reina Rodriguez F.S., Buckley C.T., Milgram J. and Kirby B.M. Biomechanical properties of feline ventral abdominal wall and celiotomy closure techniques. Veterinary Surgery, 47(2):193-203, 2018

24. Carroll, S.F., Buckley, C.T. and Kelly, D.J. Cyclic tensile strain can play a role in directing both intramembranous and endochondral ossification of mesenchymal stem cells. Front. Bioeng. Biotechnol. 5:73, 2017.

25. Gilroy D.A., Hobbs C., Buckley C.T., O’Brien F.J. and Kearney C.J. Development of magnetically active scaffolds as intrinsically-deformable bioreactors. MRS Communications 7 (3), 367-374, 2017.

26. Vedicherla S.V. and Buckley C.T. In vitro extracellular matrix accumulation of nasal and articular chondrocytes for intervertebral disc repair. Tissue and Cell. 49(4): 503-513, 2017

27. Vedicherla S.V. and Buckley C.T. Rapid chondrocyte isolation for tissue engineering applications- the effect of enzyme concentration and temporal exposure on the matrix forming capacity of nasal derived chondrocytes. BioMed Research International- Tissue Engineering 2017: 2395138.

28. Almeida H.V., Sathy B.N., Dudurych I., Buckley C.T., O‘Brien F.J. and Kelly D.J. Anisotropic shape-memory alginate scaffolds functionalized with either type I or type II collagen for cartilage tissue engineering. Tissue Engineering 23(1-2):55-68, 2017.

29. Vedicherla S.V. and Buckley C.T. Cell-based therapies for intervertebral disc and cartilage regeneration - Current concepts, parallels and perspectives. Journal of Orthopaedic Research. 35(1):8-22, 2017.

30. Luo L., O'Reilly A., Thorpe S.D., Buckley C.T. and Kelly D.J. Engineering zonal cartilaginous tissue by modulating oxygen levels and mechanical cues through the depth of infrapatellar fat pad stem cell laden hydrogels. Journal of Tissue Engineering and Regenerative Medicine. 11(9):2613-2628, 2017

31. Mesallati T., Buckley C.T. and Kelly D.J. Engineering cartilaginous grafts using chondrocyte-laden hydrogels supported by a superficial layer of stem cells. Journal of Tissue Engineering and Regenerative Medicine. 11(5):1343-1353, 2017

32. Naqvi S.M., Vedicherla S.V., Gansau J, McIntyre T, Doherty M and Buckley C.T. “Living cell factories”- Electrosprayed microcapsules and microcarriers for minimally invasive delivery. Advanced Materials, 28(27):5662-71, 2016.

33. Naqvi, S.M. and Buckley, C.T. Bone marrow stem cells in response to intervertebral disc-like matrix acidity and oxygen concentration - Implications for cell-based regenerative therapy. Spine, 41(9):743-50, 2016.

34. Almeida H.V., Eswaramoorthy, R., Cunniffe G.M., Buckley C.T., O‘Brien F.J. and Kelly D.J. Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration. Acta Biomaterialia. 36:55-62, 2016.

35. Luo L., Thorpe S.D., Buckley C.T. and Kelly D.J. The effects of dynamic compression on the development of cartilage grafts engineered using bone marrow and infrapatellar fat pad derived stem cells. Biomedical Materials, 21;10(5):055011, 2015.

36. Mesallati T., Sheehy E.J., Vinardell T., Buckley C.T. and Kelly D.J. Tissue engineering scaled-up, anatomically shaped osteochondral constructs for joint resurfacing. e Cells and Materials, 28;30:163-85, 2015.

37. Naqvi, S.M. and Buckley, C.T. Extracellular matrix production by nucleus pulposus and bone marrow stem cells in response to altered oxygen and glucose microenvironments. Journal of Anatomy, 227: 757-766, 2015.

38. Sheehy E.J., Mesallati T., Vinardell T., Kelly L., Buckley C.T. and Kelly D.J. Tissue engineering whole bones through endochondral ossification: Regenerating the distal phalanx. BioResearch, 1;4(1):229-41, 2015.

39. Sanders, R., Kearney, C, Buckley, C.T., Jenner, F. and Brama, P. Knot security of 5 metric (USP 2) sutures: influence of knotting technique, suture material, and incubation time for 14 and 28 days in phosphate buffered saline and inflamed equine peritoneal fluid. Veterinary Surgery, 44(6): 723-730, 2015.

40. Almeida H.V., Cunniffe G.M., Vinardell, T., Buckley C.T., O‘Brien F.J. and Kelly D.J. Coupling freshly isolated CD44+ infrapatellar fat pad derived stromal cells with a TGF-β3 eluting cartilage ECM-derived scaffold as a single stage strategy for promoting chondrogenesis. Advanced Healthcare Materials, 4(7):1043-53, 2015.

41. Guillaume, O., Naqvi, S.M., Lennon, K. and Buckley C.T. Enhancing cell migration in shape-memory alginate-collagen composite scaffolds: in vitro and ex vivo assessment for intervertebral disc repair. Journal of Biomaterials Applications, 29(9): 1230 – 1246, 2015.

42. Sridharan, R., Reilly, R.B. and Buckley C.T. Decellularized grafts with axially aligned channels for peripheral nerve regeneration. Journal of the Mechanical Behavior of Biomedical Materials 41: 124–135, 2015.

43. Naqvi, S.M. and Buckley, C.T. Differential response of encapsulated nucleus pulposus and bone marrow stem cells in isolation and coculture in alginate and chitosan hydrogels. Tissue Engineering Part A, 21(1-2): 288-299, 2015.

44. Aisa J., Calvo I., Buckley C.T. and Kirby B.M. Mechanical comparison of loop and crimp configurations for extracapsular stabilization of the cranial cruciate ligament-deficient stifle. Veterinary Surgery, 44(1):50-8, 2015.

45. Guillaume, O., Daly, A., Lennon K., Gansau J., Buckley S.F. and Buckley, C.T. Shape-memory porous alginate scaffolds for regeneration of the annulus fibrosus - Effect of TGF-β3 supplementation and oxygen culture conditions. Acta Biomaterialia 10: 1985–1995, 2014.

46. Almeida H.V., Liu, Y. Cunniffe G.M., Mulhall K.J., Matsiko A., Buckley C.T., O‘Brien F.J. and Kelly D.J. Controlled release of TGF-β3 from cartilage extra cellular matrix derived scaffolds to promote chondrogenesis of human joint tissue derived stem cells. Acta Biomaterialia 10(10):4400-9, 2014.

47. Baboolal T.G., Boxall S.A., Churchman S.M., Buckley C.T., Jones E. and McGonagle D. Intrinsic multipotential mesenchymal stromal cell activity in gelatinous Heberden's nodes in osteoarthritis at clinical presentation. Arthritis Research & Therapy 16(3): R119, 2014.

48. Liu Y, Buckley C.T., Almedia H.V., Mulhall K.J. and Kelly D.J. Infrapatellar fat pad derived stem cells maintain their chondrogenic capacity in disease and can be used to engineer cartilaginous grafts of clinically relevant dimensions. Tissue Engineering Part A, 20(21-22):3050-62, 2014.

49. Sheehy E.J., Vinardell T., Toner M.E., Buckley C.T. and Kelly D.J. Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation. PLOS ONE, 9(3): e90716, 2014.

50. Mesallati T., Buckley C.T. and Kelly D.J. Engineering articular cartilage-like grafts by self-assembly of infrapatellar fat pad-derived stem cells. Biotechnology and Bioengineering, 111: 1686–1698, 2014.

51. Carroll, S.F., Buckley, C.T. and Kelly, D.J. Cyclic hydrostatic pressure promotes a stable cartilage phenotype and enhances the functional development of cartilaginous grafts engineered using multipotent stromal cells isolated from bone marrow and infrapatellar fat pad. Journal of Biomechanics, 47(9):2115-21, 2014.

52. Mesallati T., Buckley C.T. and Kelly D.J. A comparison of self-assembly and hydrogel encapsulation as a means to engineer functional cartilaginous grafts using culture expanded chondrocytes. Tissue Engineering Part C, 20(1):52-63, 2014.

53. Kearney C.M., Buckley C.T., Jenner F and Brama P.A.J. Elasticity and breaking strength of synthetic suture materials incubated in various equine physiological and pathological solutions. Equine Veterinary Journal, 46(4):494-8, 2014.

54. Liu Y, Buckley C.T., Mulhall K and Kelly D.J. Combining BMP-6, TGF-β3 and hydrostatic pressure stimulation enhances the functional development of cartilage tissues engineered using human infrapatellar fat pad derived stem cells. Biomaterials Science, 1(7): 745-752, 2013.

55. O hEireamhoin*, S., Buckley, C.T.*, Jones, E., McGonagle, D., Mulhall, K.J. and Kelly, D.J. Recapitulating aspects of the oxygen and substrate environment of the damaged joint milieu for stem cell based cartilage tissue engineering. Tissue Engineering Part C, 19(2):117-27, 2013 * Both authors contributed equally to this study.

56. Sheehy E.J., Vinardell T., Buckley C.T. and Kelly D.J. Engineering osteochondral constructs through spatial regulation of endochondral ossification. Acta Biomaterialia, 9(3):5484-92, 2013.

57. Mesallati T., Buckley C.T., Nagel T. and Kelly D.J. Scaffold architecture determines chondrocyte response to externally applied dynamic compression. Biomechanics and Modeling in Mechanobiology. 12(5): 889-899, 2013.

58. Haugh M.G., Thorpe S.D., Vinardell T., Buckley C.T. and Kelly D.J. The application of plastic compression to modulate fibrin hydrogel mechanical properties. Journal of the Mechanical Behavior of Biomedical Materials, 16:66-72, 2012.

59. Thorpe S.D., Buckley C.T., Steward A.J. and Kelly D.J. European Society of Biomechanics S.M. Perren Award- The external mechanical environment can override the influence of local substrate in determining stem cell fate. Journal of Biomechanics, 45(15):2483-92, 2012.

60. Liu Y, Buckley C.T., Downey R., Mulhall K and Kelly D.J. The role of environmental factors in regulating the development of cartilaginous grafts engineered using osteoarthritic human infrapatellar fat pad–derived stem cells Tissue Engineering Part A, 18(15-16):1531-41, 2012.

61. Steward A.J., Thorpe S.D., Buckley C.T., Wagner D.R. and Kelly D.J. Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure. Acta Biomaterialia, 8(6):2153-9, 2012.

62. Buckley C.T., Meyer E.G. and Kelly D.J. The influence of construct scale on the composition and functional properties of cartilaginous tissues engineered using bone marrow-derived mesenchymal stem cells. Tissue Engineering Part A, 18(3-4):382-96, 2012.

63. Vinardell T., Rolfe R.A., Buckley C.T., Meyer E.G., Murphy P. and Kelly D.J. Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells. eCells & Materials (eCM), 23: 121 – 134, 2012.

64. Buckley C.T. and Kelly D.J. Expansion in the presence of FGF-2 enhances the functional development of cartilaginous tissues engineered using infrapatellar fat pad derived MSCs. Journal of the Mechanical Behavior of Biomedical Materials, 11:102-11, 2012.

65. Vinardell T., Sheehy E.J., Buckley C.T. and Kelly D.J. A comparison of the functionality and in vivo phenotypic stability of cartilaginous tissues engineered from different stem cell sources. Tissue Engineering Part A. 18(11-12):1161-70, 2012.

66. Sheehy E.J., Buckley C.T. and Kelly D.J. Oxygen tension regulates the osteogenic, chondrogenic and endochondral phenotype of bone marrow derived mesenchymal stem cells. Biochemical and Biophysical Research Communications, 417(1):305-10, 2012.

67. Cox G., Boxhall S., Giannoudis P.V., Buckley C.T., Roshdy T., Churchman S.M., McGonagle D. and Jones E. High abundance of CD271+ multipotential stromal cells (MSCs) in intramedullary cavities of long-bones. Bone, 50(2):510-7, 2012.

68. Ahearne M.A., Buckley C.T. and Kelly D.J. A growth factor delivery system for chondrogenic induction of infrapatellar fat-pad derived stem cells in fibrin hydrogels. Biotechnology and Applied Biochemistry, 58(5):345-52, 2011.

69. Meyer E.G., Buckley C.T., Steward, A.J. and Kelly D.J. The effect of cyclic hydrostatic pressure on the functional development of cartilaginous tissues engineered using bone marrow derived mesenchymal stem cells. Journal of the Mechanical Behavior of Biomedical Materials. 4(7):1257-65, 2011.

70. Sheehy E.J., Buckley C.T. and Kelly D.J. Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions. Journal of Tissue Engineering & Regenerative Medicine. 5(9): 747-758, 2011.

71. Cox G., McGonagle D., Boxhall S.A., Buckley C.T., Jones E. and Giannoudis P.V. The use of the reamer-irrigator-aspirator to harvest mesenchymal stem cells. Journal of Bone and Joint Surgery, British Volume. Vol 93-B(4): 517-24, 2011.

72. Vinardell T, Buckley C.T., Thorpe S.D. and Kelly D.J. Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad. Journal of Tissue Engineering & Regenerative Medicine, 5(9): 673-683, 2011.

73. Buckley C.T., Vinardell T. and Kelly D.J. Oxygen tension differentially regulates the functional properties of cartilaginous tissues engineered from infrapatellar fat pad derived MSCs and articular chondrocytes. Osteoarthritis Cartilage, 18(10):1345-1354, 2010.

74. Buckley C.T., Vinardell T., Thorpe S., Haugh M., Jones E., McGonagle D. and Kelly D.J. Functional properties of cartilaginous tissues engineered from infrapatellar fat pad derived mesenchymal stem cells. Journal of Biomechanics, 43(5): 920-926, 2010.

75. Meyer E., Buckley C.T., Thorpe S.D. and Kelly D.J. Low oxygen tension is a more potent regulator of chondrogenic differentiation than dynamic compression. Journal of Biomechanics, 43: 2516–2523, 2010.

76. Thorpe S.D., Buckley C.T., Vinardell T., O’Brien F.J., Campbell V.A. and Kelly D.J. The response of bone marrow-derived mesenchymal stem cells to dynamic compression following TGF-beta3 induced chondrogenic differentiation. Annals of Biomedical Engineering, 38(9): 2896-2909, 2010.

77. Buckley C.T. and O’Kelly K.U. Maintaining cell depth viability: On the efficacy of a trimodal scaffold pore architecture and dynamic rotational culturing. Journal of Materials Science: Materials in Medicine, 21(5):1731-38, 2010.

78. Buckley C.T. and O’Kelly K.U. Fabrication and characterisation of a porous multi-domain hydroxyapatite scaffold for bone tissue engineering. Journal of Biomedical Materials Research: Applied Biomaterials, 93B(2): 459 – 467, 2010.

79. McAlinden A.B., Buckley C.T., and Kirby B.M. Biomechanical evaluation of different numbers, sizes and placement configurations of ligaclips required to secure cellophane bands. Veterinary Surgery, 39(1): 59-64, 2010.

80. Buckley C.T., Thorpe S.D. and Kelly D.J. Engineering of large cartilaginous tissues through the use of microchanneled hydrogels and rotational culture. Tissue Engineering Part A, 15(11): 3213-3220, 2009.

81. Vinardell T., Thorpe S.D., Buckley C.T. and Kelly D.J. Chondrogenesis and integration of bone marrow derived mesenchymal stem cells and chondrocytes within an in vitro cartilage defect repair model. Annals of Biomedical Engineering, 37(12): 2556-65, 2009.

82. Buckley C.T., Thorpe S.D., O’Brien F.J., Robinson A.J. and Kelly D.J. The effect of concentration, cooling rate and cell seeding density on the initial mechanical properties of agarose hydrogels. Journal of the Mechanical Behavior of Biomedical Materials, 2(5): 512-521, 2009.

83. Thorpe S.D., Buckley C.T., Vinardell T., O’Brien F.J., Campbell V.A. and Kelly D.J. Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells. Biochemical and Biophysical Research Communications, 377(2): 458-462, 2008.

84. Buckley C.T. and O’Kelly K.U.: Development of a hydroxyapatite bone tissue engineering scaffold with a trimodal pore structure. Key Engineering Materials Vols. 361-363: 931-934, 2008.